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To extend this finding to other models, the experiment was repeated using the 4T1 mammary carcinoma genetically modified to express the influenza-derived HA as a model tumor antigen (Fig. 3 B). Mice were challenged on day 0 with 0.5 x 106 4T1-HA cells. On the next day they received 3 x 106 HA-specific naive CD8+ T cells. After adoptive transfer, the mice were either treated with sildenafil or left untreated. As with the C26GM experiments, no therapeutic benefit was observed with ACT alone, whereas sildenafil + ACT imparted the greatest antitumor benefit. Sildenafil treatment alone, instead, substantially delayed tumor progression in immunocompetent BALB/c mice but not in immune-deficient Rag-2–/– mice (Fig. S3, available at http://www.jem.org/cgi/content/full/jem.20061104/DC1). These data confirm the immunomodulatory properties of PDE5 inhibitors in augmenting the therapeutic efficacy of ACT and demonstrate a role of sildenafil in modifying the tumor microenvironment rendering it more susceptible to CTL-mediated cytotoxicity. How well does birth control work? Contraindications online viagra 25mg viagra online
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Monday, 04 June 2012
On 04 June, 2012 there was a workshop in Education faculty for female students. The workshop started with a short introduction and proceeded towards project description and its goals.
The following were the topics discussed in the workshop:
How to decrease or eradicate corruption?
How can we quicken our efforts to stimulate youth in fight against corruption?
What are the main causes of corruption in the University?
Our roles in corruption elimination!
We were provided the following ideas for a successful combat against corruption:
First, a government needs to put in place a solid set of preventive tools. Codes of Conduct and strong independent oversight bodies can help ensure that the acceptable standards of behavior are respected in both the private and public sector. Political leaders in all branches of government, legislative and judiciary can be required to have transparency in their own financial dealings through asset disclosure for themselves and their family members.
on Monday, 04 June 2012 00:00
on Wednesday, 23 May 2012 00:00
on Friday, 20 April 2012 00:00
on Monday, 16 April 2012 06:14
The Afghan NGO Coordination Bureau (ANCB) was founded in 1991 as a network of national NGOs in Afghanistan coordinating the activities among its members, with the Government, International organizations, UN and donor agencies.